Mining Deeper Into the Proteome: Computational Strategies for Improving Depth and Breadth of Coverage in High-throughput Protein Identification Studies

Mining Deeper Into the Proteome: Computational Strategies for Improving Depth and Breadth of Coverage in High-throughput Protein Identification Studies

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A newer mass spectrometry methodology useful for phosphoproteomics has recently been introduced as well, termed multistage activation (MSA). A comparative study of this and other methods is presented aimed at determining an optimal method for generating phosphopeptide identifications, focusing not only on data analysis techniques, but also on the mass spectrometry methodologies themselves.Overall, the software boosts the probabilities for peptides identified by multiple engines, and effectively permits an increase in sensitivity as a result (5). Scaffold was used to ... The Venn diagram is not area-proportional. These results suggest anbsp;...


Title:Mining Deeper Into the Proteome: Computational Strategies for Improving Depth and Breadth of Coverage in High-throughput Protein Identification Studies
Author: Peter J. Ulintz
Publisher:ProQuest - 2008
ISBN-13:

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